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Domenico di Bartolo was an Italian painter of the Sienese School. He was born sometime between 1400-1404 in Asciano and died in 1445 (or 1447). According to Vasari, he was a nephew of Taddeo di Bartolo. Employed by Vecchietta in the masterpiece fresco The Care of the Sick in the Pellegrinaio (Pilgrim’s Hall) of the Ospedale de Santa Maria della Scala in Siena.

In this painting, wealthy donors visit the hospital to find men washing the ill, and a rotund friar hearing confession. In 1434, he also painted a fresco panel of Emperor Sigismund Enthroned (Imperatore Sigismundo in trono) for the Duomo di Siena.

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